ELP3 Controls Active Zone Morphology by Acetylating the ELKS Family Member Bruchpilot

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• 作者：Katarzyna Miś ; kiewicz¹ ;   ; ² ; Liya  ; E. Jose¹ ;   ; ² ; André ; Bento-Abreu³ ;   ; ⁴ ;   ; ⁸ ; Marcus Fislage⁵ ;   ; ⁶ ;   ; ⁸ ; Ines Taes³ ;   ; ⁴ ; Jarosł ; aw Kasprowicz¹ ;   ; ² ; Jef Swerts¹ ;   ; ² ; Stephan Sigrist⁷ ; Wim Versé ; es⁵ ;   ; ⁶ ; Wim Robberecht³ ;   ; ⁴ ; Patrik Verstreken¹ ;   ; ² ;   ; ^{patrik.verstreken@cme.vib-kuleuven.be}
• 刊名：Neuron
• 出版年：2011
• 出版时间：8 December 2011
• 年：2011
• 卷：72
• 期：5
• 页码：776-788
• 全文大小：2208 K

文摘

Summary

Elongator protein 3 (ELP3) acetylates histones in the nucleus but also plays a role in the cytoplasm. Here, we report that in Drosophila neurons, ELP3 is necessary and sufficient to acetylate the ELKS family member Bruchpilot, an integral component of the presynaptic density where neurotransmitters are released. We find that in elp3 mutants, presynaptic densities assemble normally, but they show morphological defects such that their cytoplasmic extensions cover?a larger area, resulting in increased vesicle tethering as well as a more proficient neurotransmitter release. We propose a model where ELP3-dependent acetylation of Bruchpilot at synapses regulates the structure of individual presynaptic densities and neurotransmitter release efficiency.

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