The F-actin modulator SWAP-70 controls podosome patterning in osteoclasts

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• 作者：Anne Roscher^a ; Tomoka Hasegawa^b ; Sebastian Dohnke^c ; Carlos Ocañ ; a-Morgner^a ; Norio Amizuka^b ; Rolf Jessberger^a ; ¹ ; ^{rolf.jessberger@tu-dresden.de} ; Annette I. Garbe^a ; ^c ; ¹ ; ^{Annette.garbe@crt-dresden.de}
• 关键词：Actin cytoskeleton ; Podosome pattering ; Membrane binding ; PIP3 ; Swap-70 ; V-ATPase
• 刊名：Bone Reports
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：5
• 期：Complete
• 页码：214-221
• 全文大小：1765 K
• 卷排序：5

文摘

SWAP-70 controls dynamic podosome patterning but not assembly of podosomes. PIP3 and F-actin binding are required for proper subcellular localization of SWAP-70. SWAP-70-deficient osteoclasts are impaired in ruffled border formation.