EPAC1 activation enhances HAEC alignment and elongation under low FSS.
Knockdown of EPAC1 impairs HAEC morphological adaptations to low FSS and reduces the expression of flow-dependent genes.
EPAC1 mediates PECAM1/VEGFR2/VECAD mechanosensory complex assembly in HAECs.
VEGFR2 mechanosensor signaling to AKT is impaired in cells with reduced EPAC1 levels.