A case of anti-NMDA receptor encephalitis in a woman with a NMDA-R⁺ small cell lung carcinoma (SCLC)

详细信息    查看全文

• 作者：M. Jeraiby^a ; A. Depincé ; -Berger^a ; V. Bossy^a ; J.C. Antoine^b ; S. Paul^a ; ^{stephane.paul@chu-st-etienne.fr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Anti-NMDA receptor ; SCLC ; Paraneoplastic encephalitis and immunocytochemistry
• 刊名：Clinical Immunology
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：166-167
• 期：Complete
• 页码：96-99
• 全文大小：612 K

文摘

The association of small cell lung cancer with anti-m>Nm>-methyl-mallcaps">d-aspartate receptor (NMDAR) encephalitis is rare. We report a 62 year old patient who developed psychiatric disorders followed by epilepsy, movement disorders, mutism and hypoventilation. Flair weighted brain MRI sequences showed diffuse high signals in the limbic system. Anti-NMDAR antibodies were detected in the serum and CSF. The patient's IgGs reacted with the patient's own tumor cells and with 2 out of 4 small cell lung cancers of patients without neurological syndrome.