Structural features and anticancer activity in vitro of fucoidan derivatives from brown alga Saccharina cichorioides

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• 作者：Stanislav D. Anastyuk^a ; ¹ ; ^{sanastyuk@piboc.dvo.ru} ; Natalia M. Shevchenko^a ; ¹ ; Roza V. Usoltseva (Menshova)^a ; Artyom S. Silchenko^a ; Pavel A. Zadorozhny^b ; Pavel S. Dmitrenok^a ; Svetlana P. Ermakova^a
• 关键词：Fucoidan derivatives ; Structure ; Mass spectrometry ; NMR ; C-PAGE ; Anticancer activity
• 刊名：Carbohydrate Polymers
• 出版年：2017
• 出版时间：10 February 2017
• 年：2017
• 卷：157
• 期：Complete
• 页码：1503-1510
• 全文大小：1367 K
• 卷排序：157

文摘

Fucoidan ScF (80 kDa) was isolated from the brown alga Saccharina cichorioides. Polysaccharide derivatives were obtained by autohydrolysis for 24, 48 and 72 h. Pellet (PL) and supernatant (SN) fractions were obtained by ethanol precipitation. All derivatives inhibited colony formation of colorectal carcinoma cells HT-29. ScF-SN-72 derivative was 6% more active than fucoidan ScF and had MW 6 kDa.