Down-regulation of B cell-related genes in peripheral blood leukocytes of Parkinson's disease patients with and without GBA mutations
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- 作者：Hila Koboa ; c ; hilako@tlvmc.gov.il" class="auth_mail" title="E-mail the corresponding author ; Anat Bar-Shiraa ; anatbn@tlvmc.gov.il" class="auth_mail" title="E-mail the corresponding author ; Dvir Daharya ; dvir.dahary@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Ziv Gan-Ora ; ziv.gan-or@mail.mcgill.ca" class="auth_mail" title="E-mail the corresponding author ; Anat Mirelmanb ; anatmi@tlvmc.gov.il" class="auth_mail" title="E-mail the corresponding author ; Orly Goldsteina ; orlyg@tlvmc.gov.il" class="auth_mail" title="E-mail the corresponding author ; Nir Giladib ; c ; nirg@tlvmc.gov.il" class="auth_mail" title="E-mail the corresponding author ; Avi Orr-Urtregera ; c ; aviorr@tasmc.health.gov.il" class="auth_mail" title="E-mail the corresponding author
- 关键词：PD ; Parkinson's disease ; SN ; Substantia nigra ; LB ; Lewy-Bodies ; AJ ; Ashkenazi-Jewish ; GBA ; Glucosidase beta acid ; LRRK2 ; Leucine-rich repeat kinase 2 ; PBLs ; Peripheral blood leukocytes ; PD-NC ; PD patients who do not carry the most common Ashkenazi mutations in the GBA or LRRK2 genes ; PD-GBA ; PD patients with mutations in the GBA gene ; AAE ; Age at enrollment ; PCA ; Principal component analysis ; BCR ; B cell receptor ; qRT-PCR ; Quantitative real-time Polymerase chain reaction ; DD ; Disease durati
- 刊名：Molecular Genetics and Metabolism
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：117
- 期：2
- 页码：179-185
- 全文大小：557 K
文摘
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Expression changes were found in leukocytes of GBA-associated Parkinson's disease.
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Most were down-regulated in patients and related to B cell receptor signaling, BCRs.
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Decreased expression of BCR genes was replicated in patients without GBA mutations.
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These expression changes were negatively correlated with disease duration.