A chimeric virus created by DNA shuffling of the capsid genes of different subtypes of porcine circovirus type 2 (PCV2) in the backbone of the non-pathogenic PCV1 induces protective immunity against the predominant PCV2b and the emerging PCV2d in pigs
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- 作者：Shannon R. Matzingera ; Tanja Opriessnigb ; Chao-Ting Xiaoc ; Nicholas Catanzaroa ; Nathan M. Beacha ; David E. Sladed ; Gregory P. Nitzeld ; Xiang-Jin Menga ; xjmeng@vt.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Porcine circovirus type 2 (PCV2) ; Porcine circovirus-associated disease (PCVAD) ; DNA shuffling ; Capsid ; Vaccine
- 刊名：Virology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：498
- 期：Complete
- 页码：82-93
- 全文大小：1488 K
文摘
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DNA shuffling technology was used to create a candidate PCV2 vaccine containing genetic signatures of multiple PCV2 subtypes.
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The shuffled chimeric virus vaccine candidate is viable and induced anti-PCV2 neutralizing antibodies in pigs.
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The candidate PCV2 vaccine is capable of protecting against the predominant PCV2b subtype and the emerging PCV2d strain.