Cyclic nucleotide phosphodiesterases in human spermatozoa and seminal fluid: Presence of an active PDE10A in human spermatozoa

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• 作者：Loï ; ze Maré ; chal^a ; ¹ ; Christine Guillemette^b ; ¹ ; Serge Goupil^a ; Patrick Blondin^c ; Pierre Leclerc^a ; Franç ; ois J. Richard^b ; ^{Francois.Richard@fsaa.ulaval.ca}
• 关键词：Spermatozoa ; Seminal plasma ; Phosphodiesterase
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1861
• 期：2
• 页码：147-156
• 全文大小：1988 K
• 卷排序：1861

文摘

Phosphodiesterase 10 is functionally present in human spermatozoa. Experimental evidence for the presence of a predicted isoform PDE10 inhibition impacts cAMP/PKA dependent phosphorylation. PDE10 inhibition impacts protein-tyrosine phosphorylation. PDE10 inhibition impacts acrosome reaction and the acrosomal exocytosis.