Basic FGF and PDGF-BB synergistically stimulate hyaluronan and IL-6 production by orbital fibroblasts
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- 作者：Sita Virakula ; b ; 1 ; Judith W. Heutzc ; 1 ; Virgil A.S.H. Dalma ; b ; Robin P. Peetersc ; Dion Paridaensd ; Willem A. van den Boschd ; Nattiya Hirankarne ; P. Martin van Hagena ; b ; d ; Willem A. Dika ; w.dik@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Graves&rsquo ; ophthalmopathy ; Platelet-derived growth factor-BB ; Fibroblast growth factor ; Vascular endothelial growth factor ; Orbital fibroblast ; Hyaluronan
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：433
- 期：Complete
- 页码：94-104
- 全文大小：528 K
文摘
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bFGF stimulates proliferation and hyaluronan production, but not IL-6 production, by orbital fibroblasts.
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bFGF and PDGF-BB synergistically enhance hyaluronan and IL-6 production by orbital fibroblasts.
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bFGF may contribute to orbital inflammation and tissue remodeling in GO, especially by synergistic interaction with PDGF-BB.
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VEGF hardly affects orbital fibroblast activity.
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The receptor tyrosine kinase inhibitor nintedanib efficiently blocks bFGF + PDGF-BB-induced IL-6 and hyaluronan production.