Serum platelet-derived growth factor BB levels: a potential biomarker for the assessment of liver fibrosis in patients with chronic hepatitis B

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• 作者：Jiyuan Zhou^a ; ¹ ; Yongqiong Deng^a ; ^b ; ¹ ; Linlin Yan^a ; Hong Zhao^a ; ² ; ^{minmi2001@126.com" class="auth_mail" title="E-mail the corresponding author} ; Guiqiang Wang^a ; ^c ; ³ ; ^{john131212@126.com" class="auth_mail" title="E-mail the corresponding author} ; China HepB-Related Fibrosis Assessment Research Group
• 关键词：Chronic hepatitis B ; PDGF-BB ; Liver fibrosis ; Diagnosis
• 刊名：International Journal of Infectious Diseases
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：49
• 期：Complete
• 页码：94-99
• 全文大小：459 K

文摘

Few studies have investigated serum levels of platelet-derived growth factor (PDGF) in patients with chronic hepatitis B (CHB). The present study aimed to determine whether PDGF-BB could serve as a potential biomarker for the detection of liver fibrosis.

Methods

From October 2013 to August 2015, 465 patients with CHB were enrolled prospectively in this study. All patients underwent liver biopsy and staging based on the Ishak system. The serum PDGF-BB level was measured quantitatively by ELISA.

Results

The serum PDGF-BB level was negatively correlated with fibrosis stage in all patients (p = 0.003, Spearman's rho = −0.16) and was significantly different between fibrosis stages. The areas under the receiver operating characteristics curves (AUROCs) for serum PDGF-BB level and PGT score (a combination of PDGF-BB, gamma-glutamyl transpeptidase, and platelet levels) were 0.667 and 0.831, respectively, for patients with significant fibrosis and normal alanine aminotransferase (ALT) levels. The AUROCs for aspartate aminotransferase-to-platelet ratio (APRI) and fibrosis index based on four factors (FIB-4) were 0.823 and 0.821, respectively. Importantly, a cut-off value of 1.05 and 1.43, respectively, resulted in a sensitivity of 0.95 and 0.52, a specificity of 0.29 and 0.95, a positive predictive value of 0.30 and 0.79, and a negative predictive value of 0.96 and 0.86. The rate of correct diagnosis was up to 88.4% when using cut-offs of 1.05 and 1.43 for the absence or presence of significant fibrosis, respectively.

Conclusions

Serum PDGF-BB decreased remarkably as fibrosis progressed, and this could be used as a non-invasive biomarker for the assessment of fibrosis stage in patients with CHB.