Insights into ligand stimulation effects on gastro-intestinal stromal tumors signalling

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• 作者：Christelle Bahlawane^a ; ^{christelle.bahlawane@uni.lu} ; Martine Schmitz^a ; Elisabeth Letellier^a ; Karthik Arumugam^b ; Nathalie Nicot^c ; Petr V. Nazarov^c ; Serge Haan^a
• 关键词：c-KIT ; PDGFRα ; MAPK ; PI3K ; Gastro-intestinal stromal tumors ; PD0325901 ; stem cell factor
• 刊名：Cellular Signalling
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：29
• 期：Complete
• 页码：138-149
• 全文大小：1832 K
• 卷排序：29

文摘

Constitutively active Kit mutants may be stimulated by their ligand MAPK pathway is commonly activated in all investigated GIST mutants MEK inhibitor PD0325901 is efficient to inhibit GIST cells proliferation.