HLA-DQB1 genotyping in a family with narcolepsy-cataplexy
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- 作者：Mario Pedrazzoli ; Josy Covan Pontes ; Patricio Peirano ; Sergio Tufik
- 关键词：Narcolepsy ; Family ; HLA ; DQB1
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- 刊名：Brain Research
- 出版年：2007
- 出版时间：24 August 2007
- 年：2007
- 卷：1165
- 期：Complete
- 页码：1-4
- 全文大小：244 K
文摘
Expression of the immediate early gene, c-fos, was used to investigate changes in neuronal activity in forebrain regions involved in male sexual behavior following social, hormonal and/or seasonal manipulations in the male green anole. These factors all influence behavior, yet it is unclear how they interact to modify neuronal activity in forebrain regions, including the preoptic area (POA) and ventromedial nucleus of the amygdala (AMY). These regions are involved in the display of sexual behaviors in male green anoles as in many other vertebrates. To determine the effects of seasonal, hormonal and social cues on these brain areas, we investigated c-fos under environmental conditions typical of the breeding or non-breeding season in adult male green anoles that were castrated and implanted with either testosterone (T) or blank (Bl) capsules. We also manipulated social cues by exposing only half of the animals in each group to females. T enhanced courtship and copulatory behaviors, but decreased c-fos expression in the AMY. A similar, although not statistically significant, pattern was observed in the POA, and the density of c-fos+ cells was negatively correlated in that region with the number of extensions of a throat fan (dewlap) used during courtship. Therefore, it appears that in the male green anole, T may diminish c-fos expression (likely in inhibitory neurons) in the POA and AMY to create a permissive environment in which the appropriate behavioral response can be displayed.