VRK1 phosphorylates and protects NBS1 from ubiquitination and proteasomal degradation in response to DNA damage
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- 作者：Diana M. Monsalvea ; b ; Ignacio Campillo-Marcosa ; b ; Marcella Salzanoa ; b ; Marta Sanz-Garcí ; aa ; Lara Cantareroa ; b ; Pedro A. Lazoa ; b ; pedro.lazo@csic.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：VRK1 ; vaccinia-related kinase 1 ; NBS1 ; Nijmegen breakage syndrome 1 ; DDR ; DNA damage response ; IR ; ionizing radiation
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：1863
- 期：4
- 页码：760-769
- 全文大小：2994 K
文摘
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VRK1 and NBS1 form a preassembled complex in the absence of DNA damage.
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Depletion of VRK1 prevents activation of NBS1 by doxorubicin or ionizing radiation.
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VRK1 phosphorylates NBS1 in Ser343.
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Phosphorylation of NBS1 by VRK1 protects NBS1 from RNF8 induced degradation.