Molecular epidemiology of the SH (small hydrophobic) gene of human respiratory syncytial virus (HRSV), over 2 consecutive years

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• 作者：Hildenê ; r Nogueira Lima^a ; Viviane Fongaro Botosso^b ; Danielle Bruna Leal Oliveira^a ; Angé ; lica Cristine de Almeida Campos^a ; Andrea Lima Leal^a ; Tereza Souza Silva^a ; Patrí ; cia Alves Ramos Bosso^a ; Claudia Trigo Pedroso Moraes^b ; Claudionor Gomes da Silva Filho^a ; Sandra Elisabete Vieira^c ; Alfredo Elias Gilio^c ; Klaus Eberhard Stewien^a ; Edison Luiz Durigon^a ; ^{eldurigo@usp.br}
• 关键词：HRSV ; Small hydrophobic protein ; Molecular epidemiology
• 刊名：Virus Research
• 出版年：2012
• 出版时间：January 2012
• 年：2012
• 卷：163
• 期：1
• 页码：82-86
• 全文大小：272 K

文摘

Human respiratory syncytial virus (HRSV) strains were isolated from nasopharyngeal aspirates collected from 965 children between 2004 and 2005, yielding 424 positive samples.

We sequenced the small hydrophobic protein (SH) gene of 117 strains and compared them with other viruses identified worldwide. Phylogenetic analysis showed a low genetic variability among the isolates but allowed us to classify the viruses into different genotypes for both groups, HRSVA and HRSVB. It is also shown that the novel BA-like genotype was well segregated from the others, indicating that the mutations are not limited to the G gene.