Effect of protein immunogenicity and PEG size and branching on the anti-PEG immune response to PEGylated proteins

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• 作者：Xue Wan^a ; ^b ; Juankun Zhang^a ; Weili Yu^b ; Lijuan Shen^b ; Shaoyang Ji^b ; ^{jishaoyang@home.ipe.ac.cn} ; Tao Hu^b ; ^{thu@home.ipe.ac.cn}
• 关键词：Immunogenicity ; PEGylation ; Anti-PEG antibody ; Conjugation
• 刊名：Process Biochemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：52
• 期：Complete
• 页码：183-191
• 全文大小：673 K
• 卷排序：52

文摘

Anti-PEG immunity is strongly affected by the size and the number of PEG. Conjugation with BSA can decrease the anti-PEG immunity to PEGylated TT. Anti-PEG immunity is strongly affected by the immunogenicity of proteins.