2 L versus 4 L of PEG3350 + electrolytes for outpatient colonic preparation: a randomized, controlled trial

详细信息    查看全文

• 作者：Mayur Brahmania ; George Ou ; Brian Bressler ; Hin Kin Ko ; Eric Lam ; Jennifer Telford ; Robert Enns
• 关键词：BBPS ; Boston Bowel Preparation Scale ; PEG3350e ; PEG3350 + electrolytes ; OBPS ; Ottawa Bowel Preparation Scale
• 刊名：Gastrointestinal Endoscopy
• 出版年：March, 2014
• 年：2014
• 卷：79
• 期：3
• 页码：408-416.e4
• 全文大小：1126 K

文摘

| Figures/TablesFigures/Tables | ReferencesReferences

Background

Low-volume bowel preparations are ideal to ensure patient compliance, thus enabling high-quality examinations to be achieved.

Objectives

To examine the bowel-cleansing efficacy and patient tolerability of split-dose 2 L PEG3350聽+ electrolytes (PEG3350e) with 15 mg bisacodyl versus split-dose 4 L PEG3350e.

Design

Single-blinded, noninferiority, randomized, controlled trial.

Setting

Single site, university-affiliated tertiary care center.

Patients

A total of 325 consecutive patients undergoing elective outpatient colonoscopy.

Intervention

2 L of PEG3350e with 15 mg bisacodyl versus 4 L of PEG3350e, both given in a split-dose fashion.

Main Outcome Measurements

Efficacy and tolerability of a split dose of 2 L of PEG3350e with 15 mg bisacodyl. Efficacy was assessed by using the Boston Bowel Preparation Scale and Ottawa Bowel Preparation Scale. Patient satisfaction and tolerability were assessed by using a short survey.

Results

A total of 325 patients were included in the intention-to-treat analysis (51% male) with a mean 卤 standard deviation age of 56 卤 11.2 years. No statistically significant difference in cleanliness was found by using the聽Boston Bowel Preparation Scale (intention-to-treat, P聽= .381; per-protocol, P聽= .387) and the Ottawa Bowel Preparation Scale (intention-to-treat, P聽= .285; per-protocol, P聽= .334). Participants receiving 2 L of PEG3350e found the preparation easy to consume and were willing to repeat the procedure more often than the 4-L group (P聽< .001).

Limitations

Single-center study looking at outpatient colonoscopies; unable to comment on adenoma detection rate.

Conclusions

Bowel-cleansing efficacy was similar in both the 2-L and 4-L PEG3350e groups; however, patient tolerability and willingness to repeat preparation were statistically greater with the 2 L of PEG3350e with 15聽mg bisacodyl regimen.