Phospholipase Cε deficiency delays the early stage of cutaneous wound healing and attenuates scar formation in mice

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• 作者：Xiaolong Zhu^a ; ¹ ; Yue Sun^a ; ¹ ; Xin Mu^a ; ¹ ; Pan Guo^a ; Fei Gao^a ; Jing Zhang^a ; Yunjuan Zhu^a ; Xianzhi Zhang^a ; Lingling Chen^a ; Zhiwei Ning^b ; Yunfeng Bai^c ; Jiling Ren^a ; Maoqiang Man^d ; Peimei Liu^a ; ^{liupeimei63@126.com} ; Lizhi Hu^a ; ^{lizhihu@tmu.edu.cn}
• 关键词：Phospholipase Cε ; Scar formation ; Wound healing
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：26 February 2017
• 年：2017
• 卷：484
• 期：1
• 页码：144-151
• 全文大小：1996 K
• 卷排序：484

文摘

Phospholipase Cε deficiency inhibits scar formation. Phospholipase Cε involves inflammatory cytokine production during wound healing. Phospholipase Cε deficiency reduces keratinocyte migration. Phospholipase Cε deficiency decreases collagen production in vivo and in vitro.