PRDM16 Suppresses MLL1r Leukemia via Intrinsic Histone Methyltransferase Activity
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- 作者：Bo Zhou1 ; Jingya Wang1 ; Shirley Y. Lee1 ; Jie Xiong1 ; Natarajan Bhanu4 ; Qi Guo4 ; Peilin Ma1 ; 5 ; Yuqing Sun1 ; Rajesh C. Rao1 ; 3 ; Benjamin A. Garcia4 ; Jay L. Hess1 ; 5 ; Yali Dou1 ; 2 ; yalid@umich.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：21 April 2016
- 年：2016
- 卷：62
- 期：2
- 页码：222-236
- 全文大小：5241 K
文摘
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PRDM16 is a histone H3K4 methyltransferase on chromatin
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PRDM16 methyltransferase activity suppresses MLL1r leukemia in vivo
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PRDM16 provides feedback regulations on HOXA genes via activation of Gfi1b
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PRDM16 is dynamically regulated by DNA methylation in pre-leukemic cells