刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:22 January 2017
年:2017
卷:482
期:4
页码:835-842
全文大小:2252 K
卷排序:482
文摘
Leptin receptor was mostly expressed in the submandibular salivary gland tissues in the NOD/LtJ SjS model mice, while leptin was mostly expressed by the infiltrated B lymphocyte. Leptin receptro down-regulation in salivary glands attenuates the pathologic process of SjS in the NOD/LtJ mice. Leptin/OB-R signaling may be pathogenically involved in SjS and may serve as a new marker and a potential therapeutic target.