Mussel-inspired polydopamine coated mesoporous silica nanoparticles as pH-sensitive nanocarriers for controlled release

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• 作者：Qishan Zheng ; Tianran Lin ; Hanyin Wu ; Liangqia Guo ; Peirong Ye ; Yanli Hao ; Qingquan Guo ; Jinzhi Jiang ; FengFu Fu ; Guonan Chen
• 关键词：Controlled release ; Mesoporous silica nanoparticles ; Polydopamine ; Drug delivery
• 刊名：International Journal of Pharmaceutics
• 出版年：10 March, 2014
• 年：2014
• 卷：463
• 期：1
• 页码：22-26
• 全文大小：1683 K

文摘

A novel pH-sensitive controlled release system is proposed by using mussel-inspired polydopamine (PDA) coated mesoporous silica nanoparticles (MSNs) as nanocarriers. MSNs with a large pore diameter are synthesized by using 1,3,5-trimethylbenzene as a pore-expanding agent and are modified with a PDA coating by virtue of oxidative self-polymerization of dopamine in neutral pH. PDA coated MSNs are characterized by FTIR, TEM, N₂ adsorption and XPS techniques. The PDA coating can work as pH-sensitive gatekeepers to control the release of drug molecules from MSNs in response to the pH-stimulus. Doxorubicin (DOX, an anticancer drug) can be released in the acid media and blocked in the neutral media.