Posaconazole/hydroxypropyl-β-cyclodextrin host-guest system: Improving dissolution while maintaining antifungal activity
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- 作者：Peixiao Tang ; Xiaoli Ma ; Di Wu ; Shanshan Li ; Kailin Xu ; Bin Tang ; Hui Li ; lihuilab@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Posaconazole (PubChem CID ; 468595) ; Methanol (PubChem CID ; 887) ; Acetone (PubChem CID ; 180) ; Hydroxypropyl-beta-cyclodextrin (PubChem CID ; 14049689) ; Heavy water (PubChem CID ; 24602)
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：20 May 2016
- 年：2016
- 卷：142
- 期：Complete
- 页码：16-23
- 全文大小：1297 K
文摘
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Experimental methods and theoretical study are used to explore the HP-β-CD–POS complex.
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The water solubility of POS was increased by 82 times.
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Almost 90% of the loaded POS released after 10 min in the three dissolution media.
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The HP-β-CD–POS complex maintains high antifungal activities.