Nitric oxide-repressed Forkhead factor FoxE1 expression is involved in the inhibition of TSH-induced thyroid peroxidase levels
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- 作者：Marí ; a del Mar Montesinos1 ; Juan Pablo Nicola1 ; Magalí ; Nazar ; Victoria Peyret ; Ariel Maximiliano Lucero ; Claudia Gabriela Pellizas ; Ana Marí ; a Masini-Repiso ; amasini@fcq.unc.edu.ar" class="auth_mail" title="E-mail the corresponding author
- 关键词：Thyroperoxidase (TPO) ; Nitric oxide (NO) ; Thyroid stimulating hormone (TSH) ; Forkhead box protein E1 (FoxE1)
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：420
- 期：Complete
- 页码：105-115
- 全文大小：1494 K
文摘
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Nitric oxide donors decrease TSH-stimulated thyroid peroxidase (TPO) expression.
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Nitric oxide-repressed TSH-stimulated TPO expression involves the cGMP/cGK pathway.
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Nitric oxide inhibits FoxE1-dependent TPO expression.
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Nitric oxide decreases TSH-induced FoxE1 at the transcripcional level.
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FoxE1 overexpression restores nitric oxide donors-repressed TPO expression.