Definitions and outcome measures for bullous pemphigoid: Recommendations by an international panel of experts

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• 作者：Dedee F. Murrell ; MA ; BMBCh ; MD ; FACD^a ; ^{d.murrell@unsw.edu.au} ; Benjamin S. Daniel ; MBBS^a ; Pascal Joly ; MD ; PhD^b ; Luca Borradori ; MD^c ; Masayuki Amagai ; MD ; PhD^d ; Takashi Hashimoto ; MD ; PhD^e ; Fré ; dé ; ric Caux ; MD ; PhD^f ; Branka Marinovic ; MD ; PhD^g ; Animesh A. Sinha ; MD ; PhD^h ; Michael Hertl ; MDⁱ ; Philippe Bernard ; MD ; PhD^ae ; David Sirois ; DMD ; PhD^j ; Giuseppe Cianchini ; MD^k ; Janet A. Fairley ; MD^m ; Marcel F. Jonkman ; MD ; PhDⁿ ; Amit G. Pandya ; MD^o ; David Rubenstein ; MD ; PhD^p ; Detlef Zillikens ; MD^q ; Aimee S. Payne ; MD ; PhD^s ; David Woodley ; MD^r ; Giovanna Zambruno ; MD^l ; Valeria Aoki ; MD ; PhD^t ; Carlo Pincelli ; MD^u ; Luis Diaz ; MD^p ; Russell P. Hall ; MD^v ; Michael Meurer ; MD ; PhD^x ; Jose M. Mascaro Jr. ; MD^y ; Enno Schmidt ; MD^q ; Hiroshi Shimizu ; MD ; PhD^w ; John Zone ; MD^z ; Robert Swerlick ; MD^ac ; Daniel Mimouni ; MD^ad ; Donna Culton ; MD^p ; Jasna Lipozencic ; MD ; PhD^g ; Benjamin Bince ; MD^aa ; Sergei A. Grando ; MD ; PhD ; DSc^ag ; Jean-Claude Bystryn ; MD^ab ; Victoria P. Werth ; MD^s ; ^af
• 关键词：bullous pemphigoid ; consensus ; definitions ; outcome measures ; severity score
• 刊名：Journal of the American Academy of Dermatology
• 出版年：2012
• 出版时间：March 2012
• 年：2012
• 卷：66
• 期：3
• 页码：479-485
• 全文大小：790 K

文摘

Our scientific knowledge of bullous pemphigoid (BP) has dramatically progressed in recent years. However, despite the availability of various therapeutic options for the treatment of inflammatory diseases, only a few multicenter controlled trials have helped to define effective therapies in BP. A major obstacle in sharing multicenter-based evidences for therapeutic efforts is the lack of generally accepted definitions for the clinical evaluation of patients with BP. Common terms and end points of BP are needed so that experts in the field can accurately measure and assess disease extent, activity, severity, and therapeutic response, and thus facilitate and advance clinical trials. These recommendations from the International Pemphigoid Committee represent 2 years of collaborative efforts to attain mutually acceptable common definitions for BP and proposes a disease extent score, the BP Disease Area Index. These items should assist in the development of consistent reporting of outcomes in future BP reports and studies.