Cardiac Purkinje fibers and arrhythmias; The GK Moe Award Lecture 2015

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• 作者：Penelope A. Boyden ; PhD ; Wen Dun ; MD ; PhD ; Richard B. Robinson ; PhD
• 关键词：Purkinje ; Arrhythmias ; Pacemaker activity ; Calcium ; Ion channels
• 刊名：Heart Rhythm
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：13
• 期：5
• 页码：1172-1181
• 全文大小：9107 K

文摘

Purkinje fibers/cells continue to be a focus of arrhythmologists. Here we review several new ideas that have emerged in the literature and fold them into important new points. These points include the following: some proteins in Purkinje cells are specific to Purkinjes; pacemaker function in Purkinje may be similar to that of the sinus node cell; sink-source concerns about tracts/sheets of Purkinje fibers; role of I_to in arrhythmias; and genetic lesions in Purkinjes and their high impact on cardiac rhythm. Although new ideas about the remodeled Purkinje cell are not the focus of this review, one can easily imagine how Purkinjes and their function may be altered in diseased hearts.