In vitro and in vivo delivery of therapeutic proteins using cell penetrating peptides

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• 作者：Azam Bolhassani ; ^{azam.bolhassani@yahoo.com} ; ^{A_bolhasani@pasteur.ac.ir} ; Behnaz Sadat Jafarzade ; Golnaz Mardani
• 关键词：Cell penetrating peptide ; Therapeutic protein/peptide ; Cancer ; Disease ; Preclinical and clinical trials
• 刊名：Peptides
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：87
• 期：Complete
• 页码：50-63
• 全文大小：1900 K
• 卷排序：87

文摘

Cell penetrating peptides (CPPs) promote the delivery of therapeutic proteins or peptides into live cells. Noncovalent complex formation between proteins and CPPs could overcome some delivery limitations. Successful delivery of proteins mainly depends on their physicochemical properties. Effective protein transduction domains can enhance the potency of protein therapeutics.