Pseudomonas aeruginosa develops Ciprofloxacin resistance from low to high level with distinctive proteome changes

详细信息    查看全文

• 作者：Jianhe Peng ; ^{jianhepeng@gmail.com} ; Jing Cao ; Fui Mee Ng ; Jeffrey Hill
• 关键词：Pseudomonas aeruginosa PAO1 ; Drug resistance ; Ciprofloxacin ; Infectious disease proteomics ; Intracellular drug concentration
• 刊名：Journal of Proteomics
• 出版年：2017
• 出版时间：30 January 2017
• 年：2017
• 卷：152
• 期：Complete
• 页码：75-87
• 全文大小：2009 K
• 卷排序：152

文摘

P. aeruginosa developed Ciprofloxacin resistance from low level to high level. Different Ciprofloxacin concentrations selected different mutants. Multiple cellular networks in P. aeruginosa were involved in Ciprofloxacin resistance. High level resistance was associated with upregulation of mexCD-oprJ efflux pump and downregulation of quorum sensing.