Nardonaphthalenones A and B from the roots and rhizomes of Nardostachys chinensis Batal.

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• 作者：Xu Deng^a ; ^b ; ¹ ; Yi-Jing Wu^a ; ^b ; ¹ ; Ying-Peng Chen^a ; ^b ; Hong-Hong Zheng^a ; ^b ; Zhong-Ping Wang^a ; ^b ; Yan Zhu^a ; ^b ; Xiu-Mei Gao^a ; Yan-Tong Xu^a ; ^{tonyxu2015@sina.com} ; Hong-Hua Wu^a ; ^{wuhonghua2003@163.com} ; ^{wuhonghua2011@tjutcm.edu.cn}
• 关键词：Nardostachys chinensis Batal. ; Nardonaphthalenone ; Monoterpenoids ; Iridoid glycoside
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：27
• 期：4
• 页码：875-879
• 全文大小：579 K
• 卷排序：27

文摘

Nardonaphthalenones A and B (1–2), one new apo-α-carotenone (3) and four new monoterpenoids (4, 8–9 and 11), along with six known compounds (5–7, 10, 12–13) were isolated from the dried roots and rhizomes of Nardostachys chinensis Batal. Their structures were elucidated by analysis of the spectroscopic data including NMR, HRESIMS and circular dichroism data. Furthermore, the serotonin transporter (SERT)-regulating activities of these isolates were evaluated, among them compound 3 showed the strongest enhancement activity while compound 12 showed a moderate inhibition activity on SERT.