Synthesis, in vitro evaluation and molecular docking studies of novel triazine-triazole derivatives as potential α-glucosidase inhibitors

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• 作者：Guangcheng Wang ; ^{wanggch123@163.com} ; Zhiyun Peng ; Jing Wang ; Xin Li ; Juan Li
• 关键词：1 ; 2 ; 4-Triazine ; 1 ; 2 ; 3-Triazole ; Click chemistry ; α-Glucosidase inhibitor ; Molecular docking
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：125
• 期：Complete
• 页码：423-429
• 全文大小：1398 K
• 卷排序：125

文摘

We designed and synthesized a new series of triazine-triazole derivatives. All the synthesized compounds displayed potent α-glucosidase inhibitory activity. Compound 7i was found to be the most active compound. The structure-activity relationship has been discussed. Molecular docking study was carried out to reveal the interaction between enzyme and inhibitors.