- 作者：Zhe XuAuthor Vitae ; Mei Peng ; Jun Jiang ; Chun Yang ; Weigen Zhu ; Fan Lu ; Meixiao Shen ; shenmxiao7@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 刊名：American Journal of Ophthalmology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：162
- 期：Complete
- 页码：74-82.e1
- 全文大小：1818 K
Design
Reliability study.
Methods
Sixty normal subjects (60 eyes), 30 post-LASIK subjects (60 eyes), and 14 KC patients (27 eyes) were imaged with the Pentacam HR system by 2 well-trained operators. For pachymetry the cornea was divided into 4 zones: a central zone (2-mm diameter) and concentric pericentral zone (2–5 mm), transitional zone (5–7 mm), and peripheral zone (7–10 mm). The 3 concentric zones were subdivided into 8 sectors. Intraobserver repeatability and interobserver reproducibility of entire corneal thickness maps were tested by the repeatability and reproducibility coefficients, intraclass correlation coefficients, coefficient of variation, and 95% limits of agreement.
Results
From central to peripheral zones, the precision of corneal thickness measurements became gradually smaller. Central zone repeatability and reproducibility were the best in the normal, post-LASIK, and KC groups. The peripheral superior sectors showed poorer repeatability and reproducibility for all subjects. The intraobserver repeatability and interobserver reproducibility for all zones were ≤19.3 μm, ≤22.1 μm, and ≤20.7 μm, in the normal, post-LASIK, and KC groups, respectively. The intraobserver and interobserver coefficients of variation for all zones were ≤1.3%, ≤1.6%, and ≤1.6% for all 3 groups.
Conclusions
Pentacam HR system pachymetry of the entire cornea provided good precision in normal, post-LASIK, and KC corneas. Thickness measurements in the peripheral cornea should be interpreted with caution in abnormal corneas after surgery or with diseases.