Nuclear localization of Formyl-Peptide Receptor 2 in human cancer cells
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- 作者：Fabio Cattaneoa ; 1 ; Melania Parisia ; 1 ; Tiziana Fiorettia ; b ; Daniela Sarnataroa ; c ; Gabriella Espositoa ; c ; Rosario Ammendolaa ; rosario.ammendola@unina.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：FPR2 ; G protein-coupled receptors ; Nuclear localization ; Signal transduction
- 刊名：Archives of Biochemistry and Biophysics
- 出版年：2016
- 出版时间：1 August 2016
- 年：2016
- 卷：603
- 期：Complete
- 页码：10-19
- 全文大小：2317 K
文摘
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FPR2 is expressed at nuclear/perinuclear level in CaLu-6 and AGS cells.
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FPR2 sequence analysis reveals a nuclear localization signal in the third intracellular loop.
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[125I]WKYMVm specifically binds nuclear-associated FPR2.
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Stimulation of nuclear FPR2 triggers G proteins activation and enhanced ERK2, c-Jun and c-Myc phosphorylation.