High Thyroid-stimulating Hormone Levels Increase Proinflammatory and Cardiovascular Markers in Patients with Extreme Obesity

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• 作者：Jaime Hé ; ctor Gó ; mez-Zamudio^a ; Victoria Mendoza-Zubieta^b ; Aldo Ferreira-Hermosillo^b ; Marí ; o Antonio Molina-Ayala^b ; Adá ; n Valladares-Sá ; lgado^a ; Fernando Suá ; rez-Sá ; nchez^a ; Jose de Jesú ; s Peralta-Romero^a ; Miguel Cruz^a ; ^{mcruzl@yahoo.com}
• 关键词：Extreme obesity ; Hypothyroidism ; TSH ; Cardiovascular markers
• 刊名：Archives of Medical Research
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：47
• 期：6
• 页码：476-482
• 全文大小：211 K
• 卷排序：47

文摘

Obesity is an important health problem worldwide and many studies have suggested a relationship between obesity and thyroid function, with controversial results. Interestingly, high TSH levels have been involved with the presence of inflammatory state and risk for developing cardiovascular diseases in hypothyroid and obese patients. The aim in this work was to determine the prevalence of hypothyroidism in patients with extreme obesity and to determine whether their TSH levels were related to increased serum levels of inflammatory and cardiovascular markers.MethodsA cross-sectional study in 101 patients with extreme obesity (BMI ≥40) was performed. Anthropometric (weight, height and waist circumference) and biochemical (fasting glucose, glycosylated hemoglobin, triglycerides, total cholesterol, LDL-C, HDL-C and insulin) parameters were measured. TSH and FT4 levels as well as clinical exploration for diagnosis of hypothyroidism were carried out. Serum concentration of IL-10, IL-6, adiponectin, resistin, leptin, ICAM-1, VCAM-1 and E-selectin were determined.ResultsA high prevalence for diabetes (37.6%), prediabetes (50.5%), dyslipidemia (74.3%), hypertension (61.4%) and hypothyroidism (48.5%) was observed in patients with extreme obesity. The presence of hypothyroidism increased serum concentration of proinflammatory cytokines IL-6 and leptin and decreased the antiinflammatory cytokine adiponectin. In addition, serum TSH levels showed a correlation for waist circumference, weight, BMI, A1c, insulin, IL-6, leptin, ICAM-1 and E-selectin.ConclusionThere is a high prevalence for hypothyroidism in patients with extreme obesity. High levels of TSH contribute to elevate proinflammatory and cardiovascular risk markers, increasing the risk for development of cardiovascular diseases.