Chronic Amphetamine Facilitates Immunosuppression in Response to a Novel Aversive Stimulus: Reversal by Haloperidol Pretreatment

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• 作者：Basso ; Ana M. ; et. al.
• 关键词：Amphetamine ; Sensitization ; Stress ; Haloperidol ; Dopamine ; Immunosuppression ; Lymphocytes ; Delayed-type hypersensitivity reaction ; Hemagglutinin titers ; Rats
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：1999
• 出版时间：February, 1999
• 年：1999
• 卷：62
• 期：2
• 页码：307-314
• 全文大小：146 K

文摘

The effect of chronic d-amphetamine sulfate (AMPH) treatment (nine daily injections, 2 mg/kg IP) on subsequent foot shock stress-induced immunological response was investigated. In addition, the potential role of a dopaminergic (DA) mechanism in the development of chronic AMPH-induced changes in stress-influenced immune responses was characterized. Exposure to foot shock stress decreased the percentage of T-lymphocytes, and reduced the delayed-type hypersensitivity reaction (DTH) in chronically AMPH-pretreated rats relative to vehicle-treated controls. Both of those stress-induced immunosuppressive responses were no longer evident when AMPH-pretreated rats were injected with haloperidol (HAL, 1 mg/kg IP) 30 min prior to each daily AMPH injection. The present findings are indicative of a modulatory role for dopamine in the facilitating process induced by AMPH on stress-induced immunosuppressive effects. Publisher: Elsevier Science Language of Publication: English Item Identifier: S0091-3057(98)00166-X Publication Type: Article ISSN: 0091-3057 Cited by:

1. Cancela, L.M.; Basso, A.M.; Martijena, I.D.; Capriles, N.R.; Molina, V.A.,""A dopaminergic mechanism is involved in the `anxiogenic-like' response induced by chronic amphetamine treatment: a behavioral and neurochemical study""Brain Research2001pp. 179-186
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2. Yu, Qianli; Zhang, Dongqin; Walston, Michael; Zhang, Jin; Liu, Yingyin; Watson, Ronald R.,""Chronic methamphetamine exposure alters immune function in normal and retrovirus-infected mice""International Immunopharmacology2002pp. 951-962
   in/sciserv.pl?collection=journals&journal=15675769&issue=v02i0007&article=951_cmeaifinarm"">Bibliographic Pagein/sciserv.pl?collection=journals&journal=15675769&issue=v02i0007&article=951_cmeaifinarm&form=pdf&file=file.pdf"">Full Text
3. Barr, Alasdair M.; Hofmann, B.A. Candace E.; Weinberg, Joanne; Phillips, Anthony G.,""Exposure to Repeated, Intermittent d-amphetamine Induces Sensitization of HPA Axis to a Subsequent Stressor""Neuropsychopharmacology2002pp. 286-294
   in/sciserv.pl?collection=journals&journal=0893133x&issue=v26i0003&article=286_etridihatass"">Bibliographic Pagein/sciserv.pl?collection=journals&journal=0893133x&issue=v26i0003&article=286_etridihatass&form=pdf&file=file.pdf"">Full Text

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Footnotes:

1. Present Address: The Scripps Research Institute, Department of Neuropharmacology, CVN-7, 10550 North Torrey Pines Rd., La Jolla, CA 92037.