Sex and estrous cycle influence diazepam effects on anxiety and memory: Possible role of progesterone
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- 作者：Anatildes Feitosa Silvaa ; 1 ; Diego Silveira Sousaa ; 1 ; André ; Macê ; do Medeirosb ; Priscila Tavares Macê ; doa ; Anderson Henrique Leã ; oa ; Alessandra Mussi Ribeiroc ; Geison Souza Izí ; diod ; Regina Helena Silvaa ; b ; reginahsilva@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AV ; aversive enclosed arm ; AO ; open arms ; FIN ; finasteride ; MIF ; mifepristone ; NAV ; non-aversive enclosed arm ; PMDAT ; plus maze discriminative avoidance task ; %TAV ; percentage of time spent in aversive arm ; %TOA ; percentage of time spent in open arms
- 刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
- 出版年：2016
- 出版时间：3 October 2016
- 年：2016
- 卷：70
- 期：Complete
- 页码：68-76
- 全文大小：790 K
文摘
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The amnestic effect of diazepam in females is not associated with its anxiolytic action.
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Diazepam effects are modulated by the estrous cycle.
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Diazepam-induced anxiolysis and amnesia are absent during proestrus.
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Progesterone and its metabolites are related to this modulation.