Influence of single and repeated cannabidiol administration on emotional behavior and markers of cell proliferation and neurogenesis in non-stressed mice
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- 作者：Angé ; lica Pupin Schiavona ; Jé ; ssica Mendes Bonatoa ; Humberto Milania ; Francisco Silveira Guimarã ; esb ; Rú ; bia Maria Weffort de Oliveiraa ; rmmwoliveira@uem.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：% OAE ; percentage of open arm entries ; % OAT ; percentage of time spent on the open arms ; 5-HT1A ; 5-hydroxytryptamine 1A ; BrdU ; bromodeoxyuridine ; CBD ; cannabidiol ; CNS ; central nervous system ; CUS ; chronic unpredictable stress ; DAB ; 3-3&rsquo ; -diamino-benzidine ; DCX ; doublecortin ; DG ; dentate gyrus ; DNA ; deoxyribonucleic acid ; EPM ; elevated plus maze ; FTS ; forced swim test ; GAMA ; 蠏-aminobuyric acid ; GCL ; granular cell layer ; H2O2 ; hydrogen peroxide ; HCl ; hydrochloric acid ; PBS ; phosphate buffere
- 刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
- 出版年：2016
- 出版时间：4 January 2016
- 年：2016
- 卷：64
- 期：Complete
- 页码：27-34
- 全文大小：1094 K
文摘
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CBD has properties that are common to classic antidepressants in the tail suspension test (TST) in Swiss non-stressed mice.
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CBD presents dose-dependent effects on cell proliferation and neurogenesis in the hippocampus and subventricular zone (SVZ).
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The behavioral effects of repeated CBD administration may be independent of neurogenesis.