Comparative analysis of local effects caused by Bothrops alternatus and Bothrops moojeni snake venoms: enzymatic contributions and inflammatory modulations
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- 作者：Carla Cristine Neves Mamedea ; c ; carlacristinenm@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author ; Bruna Barbosa de Sousaa ; c ; Dé ; borah Fernanda da Cunha Pereiraa ; Mariana Santos Matiasa ; Mayara Ribeiro de Queiroza ; c ; Nadia Cristina Gomes de Moraisa ; c ; Sâ ; mela Alves Pereira Batista Vieiraa ; Leonilda Stanziolab ; c ; Fá ; bio de Oliveirab ; c
- 关键词：Snake venom ; Bothrops alternatus ; Bothrops moojeni ; Inflammation ; Proteases ; Phospholipases A2
- 刊名：Toxicon
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：117
- 期：Complete
- 页码：37-45
- 全文大小：1804 K
文摘
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We investigated the local effects induced by Bothrops. alternatus and Bothrops. moojeni venoms.
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Local effects of B. moojeni venom are more potent than B. alternatus venom.
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Proteases and phospholipases contribute to local effects of bothropic venoms.
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Inflammatory reaction is mediated by eicosanoid, histamine and nitric oxide.
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Anti-inflammatory treatments reduced the local effects of bothropic envenomation.