Discovering cardiac pericyte biology: From physiopathological mechanisms to potential therapeutic applications in ischemic heart disease

详细信息    查看全文

• 作者：Elisa Avolio ^{elisa.avolio@bristol.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Paolo Madeddu ; ^{paolo.madeddu@bristol.ac.uk" class="auth_mail" title="E-mail the corresponding author}
• 关键词：α-SMA ; α-smooth muscle actin ; ALK-1/5 ; activin receptor-like kinase 1/5 ; ALP ; alkaline phosphatase ; APs ; adventitial pericyte-like progenitors ; CPs ; cardiac pericytes ; CSCs ; cardiac stem cells ; ECM ; extracellular matrix ; ECs ; endothelial cells ; EMT ; epithelial-to-mesenchymal transition ; EPCs ; endothelial progenitor cells ; HGF ; hepatocyte growth factor ; LDL ; low-density lipoprotein ; MI ; myocardial infarction/ischemia ; MSCs ; mesenchymal stem cells ; NANOG ; homeobox NANOG ; NG2 ; neural/glial antigen
• 刊名：Vascular Pharmacology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：86
• 期：Complete
• 页码：53-63
• 全文大小：1478 K

文摘

Microvascular pericytes and the more recently discovered adventitial pericyte-like progenitor cells are a subpopulation of vascular stem cells closely associated with small and large blood vessels respectively. These populations of perivascular cells are remarkably abundant in the heart. Pericytes control important physiological processes such as angiogenesis, blood flow and vascular permeability. In the heart, this pleiotropic activity makes pericytes extremely interesting for applications in regenerative medicine. On the other hand, dysfunction of pericytes could participate in the pathogenesis of cardiovascular disease, such as arterial hypertension, fibro-calcific cardiovascular remodeling, myocardial edema and post-ischemic coronary no-reflow. On a therapeutic standpoint, preclinical studies in small animal models of myocardial infarction have demonstrated the healing potential of pericytes transplantation, which has been ascribed to direct vascular incorporation and paracrine pro-angiogenic and anti-apoptotic activities. These promising findings open the door to the clinical use of pericytes for the treatment of cardiovascular diseases.