Is there a common pathogenesis in aggressive periodontitis & ankylosing spondylitis in HLA-B27 patient?

详细信息    查看全文

• 作者：Neeraj Agrawal^a ; ^{dna7kgmc@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Kavita Agarwal^b ; Atul Varshney^c ; Navneet Agrawal^d ; Ashutosh Dubey^a
• 刊名：Medical Hypotheses
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：90
• 期：Complete
• 页码：63-65
• 全文大小：561 K

文摘

HLA-B27 is having strong association to ankylosing spondylitis (AS) and other inflammatory diseases collectively known as seronegative spondyloarthropathy. In literature, although the evidence for association between AS and periodontitis as well as AS and HLA-B27 are there but the association of aggressive periodontitis in HLA-B27 positive patient with AS are not there. We hypothesize that there may be a common pathogenesis in aggressive periodontitis and ankylosing spondylitis in HLA-B27 patient. A 27-years-old female presented with the features of generalized aggressive periodontitis and difficulty in walking. On complete medical examination, ankylosing spondylitis was diagnosed with further positive HLA-B27 phenotype and negative rheumatic factor. This report may open up a new link to explore in the pathogenesis of aggressive periodontitis.