Pyrazinamide-induced hepatotoxicity is alleviated by 4-PBA via inhibition of the PERK-eIF2α-ATF4-CHOP pathway

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• 作者：Hong-li Guo^a ; ^b ; Hozeifa M. Hassan^b ; ^f ; Ping-ping Ding^b ; Shao-jie Wang^b ; Xi Chen^b ; Tao Wang^b ; ^c ; Li-xin Sun^c ; ^d ; Lu-yong Zhang^b ; ^c ; ^e ; ^{lyzhang@cpu.edu.cn} ; Zhen-zhou Jiang^b ; ^d ; ^{beaglejiang@cpu.edu.cn}
• 关键词：Pyrazinamide ; Endoplasmic reticulum (ER) stress ; Hepatotoxicity ; PERK-eIF2α-ATF4-CHOP pathway ; Sodium 4-phenylbutyrate
• 刊名：Toxicology
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：378
• 期：Complete
• 页码：65-75
• 全文大小：4677 K
• 卷排序：378

文摘

Pyrazinamide induces hepatotoxicity in vitro and in vivo via activating ER stress. Pyrazinamide activates the PERK-eIF2α-ATF4-CHOP pathway. Sodium 4-phenylbutyrate ameliorates the hepatotoxicity of Pyrazinamide.