Silk biomaterials functionalized with recombinant domain V of human perlecan modulate endothelial cell and platelet interactions for vascular applications
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- 作者：Jelena Rnjak-Kovacina ; j.rnjak-kovacina@unsw.edu.au" class="auth_mail" title="E-mail the corresponding author ; Fengying Tang ; John M. Whitelock ; Megan S. Lord
- 关键词：Silk ; Perlecan ; Vascular graft ; Biomimetic ; Biomaterial
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：148
- 期：Complete
- 页码：130-138
- 全文大小：1728 K
文摘
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Perlecan is an essential vascular proteoglycan.
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C-terminal domain V of human perlecan expressed recombinantly as a proteoglycan.
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Silk biomaterials functionalised with recombinant domain V.
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Immobilization technique and glycosaminoglycan chains affected domain V orientation.
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Domain V orientation modulated endothelial cell and platelet interactions.