Knockdown of the pericellular matrix molecule perlecan lowers in situ cell and matrix stiffness in developing cartilage
详细信息 查看全文
- 作者：Xin Xua ; 1 ; Zhiyu Lib ; 1 ; Yue Lengb ; Corey P. Neua ; cpneu@colorado.edu" class="auth_mail" title="E-mail the corresponding author ; Sarah Calveb ; scalve@purdue.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Atomic force microscopy ; Mechanobiology ; Chondrocyte ; Pericellular matrix
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：418
- 期：2
- 页码：242-247
- 全文大小：1550 K
文摘
- •
Perlecan and cartilage ECM is disrupted in murine model of Schwartz-Jampel Syndrome.
- •
Stiffness of cells and surrounding ECM in E16.5 – P3 cartilage was measured via AFM.
- •
Perlecan knockdown significantly decreased cell and ECM stiffness at all timepoints.