Update on management of ovarian hyperstimulation syndrome

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• 作者：Chin-Der Chen^a ; ^b ; Ming-Ying Wu^a ; ^b ; Kuang-Han Chao^a ; ^b ; Yih-Ron Lien^a ; ^b ; Shee-Uan Chen^a ; ^b ; Yu-Shih Yang^a ; ^b ; ^{yangys@ntu.edu.tw}
• 关键词：Abdominal compartment syndrome ; Dopamine agonist ; Intra-abdominal pressure ; Ovarian hyperstimulation syndrome ; Paracentesis
• 刊名：Taiwanese Journal of Obstetrics and Gynecology
• 出版年：2011
• 出版时间：March 2011
• 年：2011
• 卷：50
• 期：1
• 页码：2-10
• 全文大小：433 K

文摘

Ovarian hyperstimulation syndrome (OHSS) is a relatively common complication of ovarian stimulation and can be life threatening. The pathophysiology of OHSS is characterized by increased capillary permeability, leading to leakage of fluid from the vascular compartment, with third-space fluid accumulation and intravascular dehydration. The increased intra-abdominal pressure indicated that OHSS may be considered a compartment syndrome. Vascular endothelial growth factor, also known as vascular permeability factor, has emerged as one of the mediators intrinsic to the development of OHSS. Conventional management is focused on supportive care until the spontaneous resolution of the condition. The standard of care for treatment—monitoring of appropriate clinical parameters, fluid balance management, thrombosis prophylaxis, and ascites treatment—should prevent severe morbidity in most cases. This review will cover inpatient and outpatient management. The potential therapeutic approach targeting the vascular endothelial growth factor system will be discussed.