Dexamethasone reverses the effects of high glucose on human retinal endothelial cell permeability and proliferation in vitro
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- 作者：E.A. Stewart1 ; E.stewart@nottingham.ac.uk" class="auth_mail" title="E-mail the corresponding author ; S. Saker1 ; msxss1@nottingham.ac.uk" class="auth_mail" title="E-mail the corresponding author ; W.M. Amoaku ; wma@nottingham.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tight junction ; Diabetic retinopathy ; Endothelial permeability ; Angiopoietin ; Dexamethasone ; Diabetic macular oedema
- 刊名：Experimental Eye Research
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：151
- 期：Complete
- 页码：75-81
- 全文大小：1244 K
文摘
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Diabetic retinopathy causes most blindness in the working population.
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Visual loss is caused by fluid (oedema) due to increased endothelial permeability.
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Hyperglycaemia increases human retinal endothelial permeability in vitro.
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Increased permeability was reversed by dexamethasone.
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Dexamethasone molecular changes induced by high glucose.