Protein import machineries of peroxisomes

详细信息    查看全文

• 作者：Robert Rucktä ; schel^a ; Wolfgang Girzalsky^a ; Ralf Erdmann ; ^a ; ^{Ralf.Erdmann@rub.de}
• 关键词：Peroxisome biogenesis ; Protein targeting ; PEX ; Peroxin
• 刊名：Biochimica et Biophysica Acta (BBA)/Biomembranes
• 出版年：2011
• 出版时间：March 2011
• 年：2011
• 卷：1808
• 期：3
• 页码：892-900
• 全文大小：493 K

文摘

Peroxisomes are a class of structurally and functionally related organelles present in almost all eukaryotic cells. The importance of peroxisomes for human life is highlighted by severe inherited diseases which are caused by defects of peroxins, encoded by PEX genes. To date 32 peroxins are known to be involved in different aspects of peroxisome biogenesis. This review addresses two of these aspects, the translocation of soluble proteins into the peroxisomal matrix and the biogenesis of the peroxisomal membrane. This article is part of a Special Issue entitled Protein translocation across or insertion into membranes.