Low bone mineral density is a common feature of Zellweger spectrum disorders
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- 作者：Eric T. Rusha ; b ; c ; erush@unmc.edu" class="auth_mail" title="E-mail the corresponding author ; Jennifer L. Goodwina ; Nancy E. Bravermand ; William B. Rizzoa ; c
- 关键词：Peroxisomal biogenesis disorder ; Zellweger spectrum disorder ; Bone mineral density ; Bone densitometry ; PPAR-gamma ; Pathologic fracture ; Bisphosphonate
- 刊名：Molecular Genetics and Metabolism
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：117
- 期：1
- 页码：33-37
- 全文大小：278 K
文摘
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Patients with ZSD have increased risk of low bone mineral density.
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Low bone mineral density does not exist primarily due to disuse or low vitamin D.
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Treatment with bisphosphonates may improve low bone mineral density.
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A mechanism for low bone mineral density involving PPAR-gamma is hypothesized.