De novo peroxisome biogenesis: Evolving concepts and conundrums
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- 作者：Gaurav Agrawal ; Suresh Subramani ; ssubramani@ucsd.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：aa ; amino acids ; ARF1 ; ADP-ribosylation-factor 1 ; APX ; ascorbate peroxidase ; BFA ; brefeldin A ; BY-2 ; bright yellow-2 ; COP ; coatomer protein ; ER ; endoplasmic reticulum ; ERES ; endoplasmic reticulum exit sites ; ERPIC ; ER-peroxisome intermediate compartment ; ERGIC ; ER-Golgi intermediate compartment ; GFP ; green fluorescent protein ; HA ; hemagglutinin ; p33 ; 33-kDa replication protein ; Pex ; peroxin ; PBD ; peroxisome biogenesis disorder ; PMP ; Peroxisomal membrane protein ; pER ; pre-peroxisomal ER ; pMVBs ; p
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：1863
- 期：5
- 页码：892-901
- 全文大小：926 K
文摘
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Peroxisomes are formed from pre-existing peroxisomes but also originate de novo by budding from the ER.
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The ER contributes to the formation of new peroxisomes as well as to the maintenance of pre-existing peroxisomes.
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The Sec61 and the Get pathway proteins are involved in import of peroxisomal membrane proteins (PMPs) into the ER membrane.
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Biochemically distinct pre-peroxisomal vesicles traffic PMPs out of the ER.
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Pex19, a cytosolic peroxin is required for the budding of pre-peroxisomal vesicles from the ER.