Pioglitazone significantly prevented decreased rate of neural differentiation of mouse embryonic stem cells which was reduced by Pex11β knock-down
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- 作者：M. Esmaeilia ; K. Ghaedia ; b ; kamranghaedi@royaninstitute.org" class="auth_mail" title="E-mail the corresponding author ; A. Shoaraye Nejatia ; M. Nematollahia ; H. Shiralyiana ; M.H. Nasr-Esfahania ; mh_nasr@royaninstitute.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Acox1 ; acyl-coenzyme A oxidase 1 ; Agps ; alkylglycerole phosphate synthase ; BSA ; bovine serum albumin ; DMSO ; dimethyl-sulfoxide ; Dox ; Doxycycline ; EBs ; embryoid bodies ; ES-FCS ; embryonic stem cells qualified-FCS ; FCS ; fetal calf serum ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase ; mESC ; mouse embryonic stem cell ; NPCs ; Neural progenitor cells ; Pax6 ; paired box gene 6 ; PBDs ; peroxisomal biogenesis disorders ; PBFE ; peroxisomal bi-functional enzyme ; PBS ; phosphate-buffered saline ; Pio ; pioglitazo
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：312
- 期：Complete
- 页码：35-47
- 全文大小：3568 K
文摘
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Decreased expression of PEX11β suppresses neural differentiation.
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10">Decreased expression of PEX11β suppresses expression level of other peroxisome-related genes.
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15">Pioglitazone pretreatment prohibited ameliorative effects of Pex11β knock down on neural differentiation.
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Pioglitazone treatment recovers expression of peroxisome-related genes.