Alcohol intake alters immune responses and promotes CNS viral persistence in mice
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- 作者：Jennifer M. Loftisa ; b ; jennifer.loftis2@va.gov" class="auth_mail" title="E-mail the corresponding author ; loftisj@ohsu.edu" class="auth_mail" title="E-mail the corresponding author ; Jonathan Taylora ; b ; taylorjo@ohsu.edu" class="auth_mail" title="E-mail the corresponding author ; Hans-Peter Raué ; c ; raueh@ohsu.edu" class="auth_mail" title="E-mail the corresponding author ; Mark K. Slifkac ; slifkam@ohsu.edu" class="auth_mail" title="E-mail the corresponding author ; Elaine Huanga ; b ; huange@ohsu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AST ; aspartate aminotransferase ; BBB ; blood brain barrier ; CNS ; central nervous system ; EtOH ; ethanol ; HCV ; hepatitis C virus ; LCMV ; lymphocytic choriomeningitis virus ; PFU ; plaque forming units
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：312
- 期：Complete
- 页码：1-8
- 全文大小：1406 K
文摘
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LCMV clone 13 infection is associated with increased alcohol intake.
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Alcohol consumption is associated with delayed viral clearance.
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LCMV-specific CD8+ T cell frequencies are reduced in mice with alcohol exposure.
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Alcohol intake may contribute to CNS viral persistence in the context of a chronic viral infection.