Conditioned medium from persistently RSV-infected macrophages alters transcriptional profile and inflammatory response of non-infected macrophages

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• 作者：Evelyn Rivera-Toledo^a ; Ivá ; n Salido-Guadarrama^b ; Mauricio Rodrí ; guez-Dorantes^b ; Laura Torres-Gonzá ; lez^a ; Carlos Santiago-Olivares^a ; Beatriz Gó ; mez^a ; ^{begomez@unam.mx}
• 关键词：Respiratory syncytial virus ; Viral persistence ; Transcriptome ; Microarray ; NLRP3 inflammasome ; Conditioned medium
• 刊名：Virus Research
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：230
• 期：Complete
• 页码：29-37
• 全文大小：1323 K
• 卷排序：230

文摘

RSV persistence induced expression of pro-inflammatory mediators in host macrophages. Soluble factors from persistently RSV-infected cells altered gene transcription in non-infected cells. Altered transcription involved an antiviral state and exacerbated inflammatory response.