Acute lung injury and persistent small airway disease in a rabbit model of chlorine inhalation

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• 作者：Sadiatu Musah^a ; Connie F. Schlueter^a ; David M. Humphrey Jr.^a ; Karen S. Powell^b ; Andrew M. Roberts^c ; Gary W. Hoyle^a ; ^{Gary.Hoyle@louisville.edu}
• 关键词：Chlorine ; Lung injury ; Rabbit ; Hypoxemia ; Bronchiolitis obliterans ; Airway hyperreactivity
• 刊名：Toxicology and Applied Pharmacology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：315
• 期：Complete
• 页码：1-11
• 全文大小：1816 K
• 卷排序：315

文摘

A novel rabbit model of chlorine-induced lung disease was developed. Acute effects of chlorine were pulmonary edema, hypoxemia and impaired lung function. Persistent small airway disease developed following recovery from acute injury. Small airway disease included inflammation and bronchiolitis obliterans lesions. The model should be useful for studying chlorine lung injury and testing treatments.