Spinal versus brain microglial and macrophage activation traits determine the differential neuroinflammatory responses and analgesic effect of minocycline in chronic neuropathic pain
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- 作者：Zhilin Lia ; zhilin.li@helsinki.fi" class="auth_mail" title="E-mail the corresponding author ; Hong Weib ; hong.wei@helsinki.fi" class="auth_mail" title="E-mail the corresponding author ; Sami Piirainena ; sami.piirainen@helsinki.fi" class="auth_mail" title="E-mail the corresponding author ; Zuyue Chenb ; zuyue.chen@helsinki.fi" class="auth_mail" title="E-mail the corresponding author ; Eija Kalsoc ; eija.kalso@helsinki.fi" class="auth_mail" title="E-mail the corresponding author ; Antti Pertovaarab ; antti.pertovaara@helsinki.fi" class="auth_mail" title="E-mail the corresponding author ; Li Tiana ; d ; li.tian@helsinki.fi" class="auth_mail" title="E-mail the corresponding author
- 关键词：Neuropathic pain ; Spared nerve injury ; Spinal cord ; Prefrontal cortex ; Microglia/macrophages ; Minocycline
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：58
- 期：Complete
- 页码：107-117
- 全文大小：2448 K
文摘
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Basal microglial/macrophage profiles in the spinal cord (SC) and brain were different.
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SNI induced differential microglial/macrophage responses in the SC and prefrontal cortex.
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Intrathecal minocycline treatment alleviated allodynia at early but not late stage.
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Minocycline dampened spinal but not cortical microglial/macrophage pro-inflammatory activation.
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Treatment targeting both spinal and brain inflammation may be more effective in pain control.